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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETDB1 All Species: 22.12
Human Site: Y251 Identified Species: 69.52
UniProt: Q15047 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15047 NP_001138887.1 1291 143157 Y251 G N H I A Y D Y H P P A D K L
Chimpanzee Pan troglodytes XP_524864 1412 156345 Y371 G N H I A Y D Y H P P A D K L
Rhesus Macaque Macaca mulatta XP_001106711 1328 147160 Y288 G N H I A Y D Y H P P A D K L
Dog Lupus familis XP_540304 1294 143238 Y251 G N H I A Y D Y H P P A D K L
Cat Felis silvestris
Mouse Mus musculus O88974 1307 144530 Y251 G N H I A Y D Y H P P A D K L
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q6INA9 1269 141759 Y245 G N H I A Y D Y H P P P E N L
Zebra Danio Brachydanio rerio Q08BR4 1216 135792 N210 K Q D S I K I N M T L L G K K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392624 1059 120586 H52 C F N A A L E H Q K Q L V T A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 91.1 96.3 96.4 N.A. 91.3 N.A. N.A. N.A. N.A. 68.4 54.6 N.A. N.A. 30.5 N.A. N.A.
Protein Similarity: 100 91.2 96.5 97.5 N.A. 94.4 N.A. N.A. N.A. N.A. 77.9 67.3 N.A. N.A. 48.2 N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 100 N.A. N.A. N.A. N.A. 80 6.6 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 N.A. N.A. N.A. N.A. 86.6 6.6 N.A. N.A. 26.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 13 88 0 0 0 0 0 0 63 0 0 13 % A
% Cys: 13 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 13 0 0 0 75 0 0 0 0 0 63 0 0 % D
% Glu: 0 0 0 0 0 0 13 0 0 0 0 0 13 0 0 % E
% Phe: 0 13 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 75 0 0 0 0 0 0 0 0 0 0 0 13 0 0 % G
% His: 0 0 75 0 0 0 0 13 75 0 0 0 0 0 0 % H
% Ile: 0 0 0 75 13 0 13 0 0 0 0 0 0 0 0 % I
% Lys: 13 0 0 0 0 13 0 0 0 13 0 0 0 75 13 % K
% Leu: 0 0 0 0 0 13 0 0 0 0 13 25 0 0 75 % L
% Met: 0 0 0 0 0 0 0 0 13 0 0 0 0 0 0 % M
% Asn: 0 75 13 0 0 0 0 13 0 0 0 0 0 13 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 75 75 13 0 0 0 % P
% Gln: 0 13 0 0 0 0 0 0 13 0 13 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 13 0 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 13 0 0 0 13 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 13 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 75 0 75 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _